hcg level after 14 days of embryo transfer forum hcg level after 14 days of embryo transfer forum

Everyone is different and Hcg loves aren't a good indicator of twins-you need an ultrasound to know for sure. The hCG value was 678 (564-815) IU/l1 on the 14th day after ET in pregnancy ended in delivery, 321 (216-477) IU/l on average in abortion, 82 (51-132) IU/l in biochemical pregnancy and 1070 (737-1554) IU/l in multiple pregnancy. The single -hCG value >410.8IU/L indicated that 76.62% of live births and a value below that threshold, resulted in 80.72% of non-live births [8]. Probabilities of each type of outcome related to the HCG level are given. Praying for two healthy babies and an easy pregnancy for you! Good luck! 2017;35:2728. Live birth indicated a pregnancy that continued after 28weeks of gestation with a live fetus evident. Best of luck to you and congratulations! Today (8/28/19, so 10 days post transfer) I had bloodwork done and got the exciting call that I am pregnant! RESULTS: Singleton intrauterine (n=91) and ectopic gestations (n=14) were analyzed. Im now 22 weeks. ROC curve analysis showed that a predicted value of -hCG for clinical pregnancy was 58.8 mIU/ml with an area under the ROC curve (AUC) of 0.752, a sensitivity of 95.0% and specificity of 53.5%. Has anyone had such high numbers after an embryo transfer? Quantitative variables with a heterogeneous variance were expressed as the median (1st and 3rd quartiles), and the medians were compared by the Mann-Whitney U test. government site. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Learn more about. If the level was between 300 and 600, the ongoing pregnancy rate was 40% (10/25). Epub 2020 Oct 9. 2022 Jan 17;26(1):62-67. doi: 10.5935/1518-0557.20210054. 2011;96:13626. Unauthorized use of these marks is strictly prohibited. 2017 Jan;33(1):62-66. doi: 10.1080/09513590.2016.1203894. Xiong F, Li G, Sun Q, Chen P, Wang Z, Wan C, et al. For patients without follicular development, an artificial cycle was given. I had 460 @ 10dpt, 3500 @ 14dpt and was twins. Cells that eventually become the placenta and fetus have begun to develop. Advice, please! The study by Stone et al., showed that the doubling times of serum -hCG (-t2) increased from 1.6days on day 12, to a doubling time 3days on day 24 after embryo transfer [11], suggesting that -hCG doubled more quickly in early pregnancy. By using this website, you agree to our I am very curious, 2 weeks post IVF 5-day, 2 blastocyst embryo transfer and beta results, Blastocyst day 5 transfer on 23rd January. This may cause vanishing twin syndrome, which may affect initial serum -hCG levels. After an embryo transfer procedure, it takes around 10-14 days to see the IVF results. sharing sensitive information, make sure youre on a federal And finally, no vanishing twin syndrome occurred in the setting of a twin pregnancy, with the notable exception of 14 total miscarriages. The HCG hormone level in the blood doubles every 48-72 h. If the HCG level doubles well, this indicates that the cells of the embryo are dividing well . Based on these factors and a few others, her IVF success rate is 33.1% using donor eggs. The detection range lied between 1.2 and 225,000 mIU/ml. Did you do PGS? The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). On 7th of June was 421. Predictive value of initial serum human chorionic gonadotropin levels for pregnancies after single fresh and frozen blastocyst transfer. official website and that any information you provide is encrypted Still told chances were minuscule for twins. Statistical analysis was performed with SPSS version 22.0 software (IBM, Armonk, NY, USA). After 5 years of trying to conceive without any success, My husband and I had decided to try IVF and we were very lucky to success on the first try. Patients undergoing in vitro fertilization (IVF) and ET were monitored by serum quantitative hCG levels 14 days after ET. This is all very nerve racking. In this pregnancy ( transfer of two embryos was recently done on 04/12/18) my hcg level at 11 days after transfer was 1200 and on day 13 4000. J Assist Reprod Genet. Oron et al., demonstrated that for -hCG that was measured 11days after single blastocyst transfer, the optimal cut-off value for predicting clinical pregnancy was 137IU/L with a PPV of 85% and an NPV of 75% [6]. Singh N, Begum AA, Malhotra N, Bahadur A, Vanamail P. J Hum Reprod Sci. 1993 May;59(5):1081-9. doi: 10.1016/s0015-0282(16)55932-9. and transmitted securely. For patients with a declined serum -hCG, another serum -hCG test should be scheduled 710days later, since abnormal conception like ectopic pregnancy can occur, similar to the case of ectopic pregnancy in our present study. Setting: At this point, if the embryo has implanted, you will also get a positive urine pregnancy test. Are you getting the testing done? . Normally, you do your first pregnancy test (HCG blood test) 14 days after embryo transfer. Hello Everyone! Congrats. If the level was less than 300, the ongoing multiple pregnancy rate was 9% (5/57). Unable to load your collection due to an error, Unable to load your delegates due to an error. An immunochemiluminometric assay was undertaken to assay for -hCG (Architech i2000SR; Abbott Laboratories Inc., Chicago, IL, USA). Has anyone needed more HCG on top of progesterone at this stage? Among the 241 clinical pregnancies, 225 (93.4%) were singletons and 16 (6.6%) were twins (i.e., 9 monozygotic twins and 7 dizygotic twins). My levels were 1,131 and that was 10dp5dt, retested on 12dp5dt (FET of two blasts) and it was 2,275 and I have 6 month old twin girls :) your levels do seem high!! We use data about you for a number of purposes explained in the links below. I was so anxious and was preparing for the worse so I was shocked to hear two heartbeats. For these reasons, it is very important to make individualized follow-up plans according to different serum -hCG intervals. You may find out you have one crazy pile of hormone releasing singleton. Beta tests appear to be incredibly common in other countries, even sometimes seeming routine. It has been reported that the quantitative serum hCG level 14 days after embryo transfer (ET) correlated with pregnancy outcome as well as a likelihood of a multiple gestation pregnancy. Careers. The .gov means its official. All authors read and approved the final manuscript. The probability of live birth was 63.6% if the fold increase was >1.9, as compared with the minimal likelihood of live birth (7.7%) in patients with a fold increase of <1.9. Zhang X, Barnes R, Confino E, Milad M, Puscheck E, Kazer RR. Shamonki et al., confirmed that declining serum -hCG levels almost always led to a failed live birth, although they reported 3 cases of live birth with declined serum -hCG levels in a cohort of 6021 patients [10]. Thank you for your reply. Ive found this calculator to be accurate, at least in my experience. Kathiresan AS, Cruz-Almeida Y, Barrionuevo MJ, Maxson WS, Hoffman DI, Weitzman VN, Christie DR, Manko GF, Ory SJ. Epub 2011 Nov 1. I have transferred two frozen embryos on May 22nd and my first beta on May 31st was 28. Your levels are almost identical to mine. Second, all included patients had adoptively received only vitrified-warmed blastocysts and had serum -hCG levels that were measured on exactly the same day after embryo transfer, which can increase the accuracy of serum -hCG levels. Initially low serum -hCG levels 14days after frozen blastocyst transfer indicated minimal chances of live birth. However, my nurse said that some women who carry twins have reported passing "tissue". Hi! Hope to see you back on site if you confirm multiples! 63, Duobao Road, Guangzhou, Guangdong, China, You can also search for this author in Since it is detected in maternal serum as soon as 68days after fertilization, -hCG is widely used in the clinic as a marker of pregnancy. Cycles where women underwent IVF with subsequent autologous fresh or frozen embryo transfer (ET), had a serum hCG >5 mIU/mL 8 or 10 days after ET, and had an US performed between 5 0/7 and 6 6/7 weeks that did not demonstrate a viable multiple gestation . I undergone with ivf on 26 August and on 9 September I did beta hcg test it was 44.34 again same day I did beta hcg it was 51.80. hCG (Human Chorionic Gonadotropin) is the "pregnancy hormone." It is detected soon after implantation and typically doubles every 72 hours. Oron G, Shavit T, Esh-Broder E, Weon-Young S, Tulandi T, Holzer H. Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer. Hi! The spontaneous miscarriage rate was, therefore, 19.8% (22/111). Google Scholar. tive value of - hCG levels following a day 5 embryo transfer in comparison to predictive values after a day 3 embryo transfer. The threshold for live birth was 1.9 with an AUC of 0.808, a sensitivity of 88.5% and specificity of 64.5%. Create an account to follow your favorite communities and start taking part in conversations. These patients are often in a state of anxiety, and tend to be concerned about the possibility of a poor prognosis. I "pray" that both my little babies do well. Craciunas L, Tsampras N, Coomarasamy A, Raine-Fenning N. Cochrane Database Syst Rev. I'd be happy with a healthy singleton. 1989 Feb;51(2):304-9 The effects of low-dose human chorionic gonadotropin combined with human menopausal gonadotropin protocol on women with hypogonadotropic hypogonadism undergoing ovarian stimulation for in vitro fertilization. Many women who feel nauseous say they feel sick to their stomach around two weeks after missing their period. 6 weeks LMP: 1,080 . We transferred 2 x 4AA blasts. Correspondence to Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle. Accessibility Prediction of patients that have had an hCG test other than 14days should be calculated according to the hCG doubling time of 48h, which limits its wider application. One study found that median hCG levels on Day 13 after a fresh embryo transfer were 329 for women with one baby and 544 for women carrying twins. The cookies is used to store the user consent for the cookies in the category "Necessary". Above 6,000 mIU/ml, the hCG often takes over four days to double. I am currently on my second pregnancy thru IVF. To examine patients after embryo transfer for predictive influence of the human chorionic gonadotropin (hCG) level on the probability of finishing pregnancy with delivery. MeSH So I was afraid of the trauma to the embryo if they biopsied after thawing and then refroze. Nearly 50% (47.4%) of the patients were early miscarriage and the rate of ectopic pregnancy was as high as 9.6%. Hcg 13 days after transfer was 1389 e2 - 2302 progesterone-17.4. Papageorgiou TC, Leondires MP, Miller BT, Chang AS, Armstrong AB, Scott LA, et al. Obstetric and perinatal outcomes of pregnancies according to initial maternal serum HCG concentrations after vitrified-warmed single blastocyst transfer. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. In the present study, pregnancy outcomes of patients whose serum -hCG levels were<300 mIU/ml 14days after blastocyst transfer were investigated. If the level was between 300 and 600, the ongoing pregnancy rate . That's wonderful! 2020. p. 16. Get the IPS Communities App for iPhone now. Disclaimer. This Cookie is set by the GDPR plugin and is used to store whether or not the user has consented to the use of Cookies. Conversely, when the hCG on day 15 was below 150 mIU/mL and the ratio of hCG on day . statement and ktberry, your levels were 2/3 mine. I am not part of the fertility board but I will look into it. Thank you Shwhite. Today is the 12th day after Embryo transfer, i couldnt wait so i bought a Home Pregnancy Kit (which claim it can detect HcG at low levels. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Would you like email updates of new search results? Clin Endocrinol (Oxf). On the contrary, an increasing frequency of abortions depending on the increasing age of the mother was once again confirmed. I'm 33, but my OB tested me anyway and it is so reassuring! 2009;91:17604. If the hCG level was greater than 600, the multiple pregnancy rate was 100% (7/7). Clipboard, Search History, and several other advanced features are temporarily unavailable. There can be a higher initial hCG trend increase with multiples, says Maureen Baldwin, M.D., MPH, an assistant professor of Obstetrics and Gynecology at Oregon Health and Science University . Among patients having a clinical pregnancy, about 60% were early miscarriage and 12.4% were ectopic pregnancy (data not shown). I am pregnant with identical twin boys! I had another beta yesterday and 48 hours later and came back 270. Hello I am 42 years old and this is my first ivf. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). To keep all these cookies active, click the Accept button. 2019;38:45564. When an initial serum -hCG is <58.8 mIU/ml, luteal phase support should be discontinued and serum -hCG measured with ultrasound one week later. If there's any concern about a high hCG level, your doctor will review the test results and discuss the next steps. It is used to diagnose pregnancy and a result greater than 5 mIU/mL is generally considered positive. Good luck! For women that have had an HCG injection as part of their fertility treatment, the hormone takes about 5-14 days to clear from her system, depending on the dose and the individual woman. Blastocyst transfer was done 5days post-ovulation. hCG levels, IVF. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Beta is in 3 days (1 Feb 2018). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. It can take up to a couple of weeks from transfer day until the placenta cells start producing enough of the hormone known as human chorionic gonadotropin (hCG) to be detected by a blood. Below are the average hCG levels during the first trimester: 3 weeks LMP: 5 - 50 mIU/ml 4 weeks LMP: 5 - 426 mIU/ml 5 weeks LMP: 18 - 7,340 mIU/ml The whole rechecking causes me a lot of stress and agony.. Hello again, Im completely scared to death I had another beta test yesterday, June 16th and the result was 2078. Please enable it to take advantage of the complete set of features! Human chorionic gonadotropin levels after blastocyst transfer are highly predictive of pregnancy outcome. Before Our research had merely included patients with initially low serum -hCG levels, instead of all pregnant women, since there have been many studies like that. I think I will do CVS but was looking into cell free fetal DNA testing, which is the newest non-invasive screening test. The threshold for live births was 108.6 mIU/ml with an AUC of 0.649 (95% CI: 0.0.5830.715), a sensitivity of 93.1%, and a specificity of 37.0% (Fig. The answer here, therefore, is a multinomial variable with four levels. The hCG level grows exponentially in the course of the 9th to 17th day after an embryo transfer (ET). Among patients with -hCG levels of 51100 mIU/ml, it was found that 55.8% were early miscarriages, 25.0% were biochemical pregnancies, and only 7.7% were live births. I would love to have twins but am afraid of the possible complications. If its doubling, then it means that everything is going as expected. Perform beta hcg test 14 days after embryo transfer. For patients having an initial -hCG >58.8 mIU/ml, luteal phase support should continue. The risk of adverse pregnancy (AP) outcomes such as ectopic pregnancy (EP), biochemical pregnancy (BP) and spontaneous abortion (SA) is greater in women undergoing ART compared with natural pregnancy. An hCG level under 5 is considered negative. My HCG 13 days after my 5 day embryo transfer was over 1,300 and my 16 day post-transfer test showed over 3,500. Twins & Multiples: Your Tentative Time Table. The probability of one child delivery after the transfer of one embryo overdue after prolonged cultivation (96 or 120 hrs) grows with the average and above-average hCG values on the day of the draw. California Privacy Statement, There can always be complications but also know there are so many healthy twin pregnancies on this board. Terms and Conditions, Results: Unauthorized use of these marks is strictly prohibited. If within 14 days of the embryo transfer, uncontrollable bleeding similar to that of a period appears, it is essential to go to, or call, the reproductive center where the treatment was performed. Thanks Sammipacheco11. I am also 43, I had one 5 day frozen transfer almost 25 weeks ago. Values about 130 mIU/ml indicate that youre 3-4 weeks pregnant. Check this chart to learn more about normal beta hCG levels during pregnancy: Normal hCG levels in pregnancy chart. Good luck to you! Thank you. Were you part of the fertility board? Then after 2 days I repeated test it is now 97.79. I had it done at Cedar Sinai with Dr. Williams, who has done about 27,000 CVS procedures and has had good results compared to other clinics. Yes 12 days. Epub 2016 Jul 22. I didn't know the gestational age for frozen embryo transfers were from the day of embryo transfer. Vitrification and thawing kits (KitazatoBiophamaCo. Ltd. Shizuoka, Japan) were applied for blastocyst cryopreservation and thawing. Also, the loss rate with CVS (and amnio) is provider -dependent so make sure you find a doctor that has ton a ton of themexperienced practitioners can have much lower rates of loss, like 1/1000. Then the blastocysts were placed into a Cryotop and placed immediately into liquid nitrogen. Thank you for sharing. Federal government websites often end in .gov or .mil. Our study showed that pregnancy outcomes of the patients with initially low serum -hCG levels were poor, with only 18.6% of live births. Quantitative variables with a homogenous variance were expressed as XSD and the means were compared by the Students t-test. Hi 10 days past day 5 embryo transfer first hCG test 211 is this a good numbers for the first beta test please help me i'm afraid that this is not goo? Early Maternal Serum -human Chorionic Gonadotropin Measurements After ICSI in the Prediction of Long-term Pregnancy Outcomes: A Retrospective Cohort Analysis. The effect of serum -hCG on pregnancy outcomes was explored by logistic regression analysis. Roughly. Although many previous studies have investigated the prediction of pregnancy outcomes by measuring serum -hCG levels after blastocyst transfer, no study has yet focused on pregnancy outcomes of patients with an initially low serum -hCG level. Asked for Female, 27 Years 2080 Views v. The study by Xiong et al., determined that optimal thresholds were 152.2IU/L and 211.9IU/L respectively in predicting clinical pregnancy and live births in patients that had -hCG tests 11days after vitrified-warmed blastocyst transfer [7]. One hundred eleven patients had positive serum quantitative hCG levels 14 days post-ET; 89/111, or 80.2%, had ongoing pregnancies. Our laboratory is annually screened for qualification by the External Quality Assessment of a Clinical Laboratory Center (Ministry of Health of the Peoples Republic of China, Beijing, China). These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. 1986 Apr;45(4):526-31 The gynae said "tentative congratulations" and also said that it may be just to early to see anything in the second sack but likely not twins. For patients with -hCG levels of 101200 and 201299 mIU/ml, the likelihood of live births was about 1/4 (i.e., 23.7 and 24.5%, respectively) and the probability of early miscarriage was about 1/2 (i.e., 50 and 51.9% respectively; Table2). -, Fertil Steril. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Patients with low -hCG values are often very anxious about their pregnancy outcomes. An official website of the United States government. Reprod BioMed Online. How are feeling? National Library of Medicine Symptoms after embryo transfer during IVF treatment: from personal experience. :). HYL analyzed the data. On day 12 following embryo transfer, serum hCG level of each patient was determined by a fluoroimmunometric assay system. If the level was less than 300, the ongoing multiple pregnancy rate was 9% (5/57). Beta hCG levels are increasing as you have witnessed yourself after the 4th of June. Slightly: The first HCG level after ivf embryo transfer gives only a rough idea of success. This is why your clinic will. Best of luck to you too! Group Black's collective includes Essence, The Shade Room and Naturally Curly. When to Call Your Doctor The rate at which serum total beta-subunit human chorionic gonadotropin increases after embryo transfer is a predictor of the viability of pregnancy and an identifier of determinants of pregnancy. Day 11: The embryo is surrounded by fluid inside the amniotic sac. The site is secure. Clipboard, Search History, and several other advanced features are temporarily unavailable. Im so worried and confused. These cookies ensure basic functionalities and security features of the website, anonymously. You will probably get a lot of responses about checking the posts at the top of the page because they remind people that hormone levels are not an indication of a pregnancy with multiples. government site. Then I didn't even get anymore blood work. For patients with a regular menstruation cycle, the natural cycle was the first choice and blastocysts were transferred 5days post-ovulation. Serum -hCG assays were done 14days after embryo transfer. I was 38 when my twins were born and my MFM suggested that I do all non-invasive screenings plus an early anatomy scan at 16 weeks and then if anything came back abnormal we could elect to do an amnio as I was worried about doing the CVS (though I had assumed I would do it before I got pregnant). Biochemical pregnancy loss was defined as a serum -HCG level>5mIU/ml 14days after transferring the embryo, which declined to <5 mIU/ml at the end of pregnancy without a visible gestational sac by ultrasound. Fertil Steril. PubMedGoogle Scholar. Generally, hCG maintains progesterone levels during the beginning of pregnancy, which supports healthy uterine and fetal growth. I was just curious what #'s you all got (if you were being monitored because of trouble conceiving) and how many babies that turned out to be. \), https://doi.org/10.1186/s13048-020-00732-6, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. This site needs JavaScript to work properly. Congrats either way and let us know what happens after your first US! Wishing for happy baby or babies for both of us ?? The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not the user has consented to the use of Cookies. A good friend transferred 2 embryos and her levels were only in the 500s after 14 days. Epub 2018 May 2. One had a heartbeat of 120 bpm and the other only 110. Its rising, but not doubling up, not even close. Article Serum hCG values for viable and non-viable pregnancies were compared by Student's t test. Journal of Ovarian Research The authors declare that they have no competing interests. tomorrow, Friday the 8th, cause she wants to make sure its doubling.. It's produced by your placenta after conception. Please be sensitive and kind. Please specify a reason for deleting this reply from the community. Prognostic value of beta-human chorionic gonadotropin is dependent on day of embryo transfer during invitro fertilization. HCG is short for human chorionic gonadotropin. Most of them were biochemical pregnancies (77.8%) and the remainder were early miscarriages (13.9%) and ectopic pregnancies (8.3%). When the hCG level on day 15 was 150 mIU/mL and an hCG day 22/hCG day 15 ratio of 15 with a specificity of 94% and sensitivity of 47% for normal pregnancy. Between 1,200 and 6,000 mIU/ml serum, the hCG usually takes 72-96 hours to double. Oral estrogen (Estradiol Valerate, Bayer, Germany) at 3mg given twice daily, was started at 24days of the cycle and continued for at least 7days. Methods: Would have been happier with one for the risk and decreased worry but after told I miscarried was so grateful to see two still on ultrasound. A risk of a heterotopic pregnancy (one embryo develops in the uterus, while the other develops in the fallopian tube) is about 1%. I truly understand as an older mom the emotions! Prediction of pregnancy outcomes is performed with the intent of developing an appropriate clinical follow-up strategy. Nevertheless, they demonstrated that the 2.37- and 2.6-fold values respectively predicted 89.8% of clinical pregnancies and 72.7% of live births [1]. First, we only analyzed patients with low serum -hCG levels instead of investigating all pregnant patients, which will be helpful in developing appropriate suggestions of follow-up for this group of patients. Higher -hCG levels are indicative of better pregnancy outcomes including higher rates of clinical pregnancy and live births [9]. The fold increase in clinical pregnancies and live births in our research was lower than those found in Sungs study. These data support the hypothesis that hCG levels greater than 200 mIU/ml on 14 days post-ET are more likely to have ongoing pregnancies; hCG levels greater than 600 have a high likelihood of a multiple gestation pregnancy. I am currently 23 w tomorrow with twins. More information on the. Research on hCG Levels After IVF Result was negative. !..is it a miscarriage??? It reaches its peak by 8-11 weeks of pregnancy and levels off. Serum hCG-beta levels of postovulatory day 12 and 14 with the sequential application of hCG-beta fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle. This study was approved by the ethics committee of the Third Affiliated Hospital of Guangzhou Medical University. Early Serum hCG in IVF: Are We Trending in the Right Direction. Zhao WE, Li YJ, Ou JP, Sun P, Chen WQ, Liang XY. At my age, I definitely need to screen for abnormalities. By continuing to browse our site you agree to our use of data and cookies. Baseline characteristics, including female and male age, number of prior pregnancies and previous transfers, anti-mllerian hormone (AMH), and body massive index (BMI) were comparable for both groups. Stone BA, Vargyas JM, Ringler GE, March CM, Marrs RP. It does not store any personal data. Results: One hundred eleven patients had positive serum quantitative hCG levels 14 days post-ET; 89/111, or 80.2%, had ongoing pregnancies. official website and that any information you provide is encrypted I read that high HCG can occur when there are abnormalities but it sounds like my numbers are more normal than I thought. For patients with decreased -hCG levels, 96.8% (30/31) were biochemical pregnancy loss. A combination of hCG levels on day 15 and 22 after embryo transfer can predict pregnancy outcome. I heard hcg doubles every 48 hours, does this apply to whatever baseline we have? Results: One thousand three hundred forty cycles involving a single embryo were analyzed. I am on 1ml progesterone oil intramuscular every day, three times per day 200mg progesterone suppositories, baby aspirin once a day and estragon patches, four, 100mg every other day. What is Assisted Reproductive Technology? 2001;76:9817. In two recent studies of Yarali et al and lvarez et al,13 14 25 mg subcutaneous progesterone was added if progesterone level 1 day before embryo transfer was below the cut-off. Your post will be hidden and deleted by moderators. Im officially six weeks and 2 days. The hCG value was 678 (564-815) IU/l1 on the 14th day after ET in pregnancy ended in delivery, 321 (216-477) IU/l on average in abortion, 82 (51-132) IU/l in biochemical pregnancy and 1070 (737-1554) IU/l in multiple pregnancy. This study was supported by the National Natural Science Foundation of China (No.81801532, to HYL and No.81701518, to YY) and Scientific Research Program of The Third Affiliated Hospital of Guangzhou Medical University (No.2017Q15, to YXW). Also, the egg retrieval procedure and the later embryo transfer can cause slight cramping in the days immediately after. A few previously reported studies investigated the prediction of pregnancy outcomes by serum -hCG levels over various days following vitrified-warmed blastocyst transfer. Once I hear a heartbeat on Tue (crossing my fingers), I will do lots of research on this but what many woman are doing on this board sounds reasonable. If you want to disable these cookies click the Configure button. For the -hCG fold increase over 48h, the cut-off for a clinical pregnancy was 1.4 with an AUC of 0.899 (95% CI: 0.8010.996), a sensitivity of 90.3%, and a specificity of 77.8%.